Which medication should be used with caution in patients with osteoporosis?
Risedronate (risedronate sodium) is a type of medicine called a bisphosphonate. It helps your bones stay as strong as possible. It can help if you have or are at risk of getting a health problem called osteoporosis. This is where your bones get weaker and more likely to break. Osteoporosis can happen for many reasons, but you're more likely to get it if you're a woman who has been through the menopause or if you take steroids, such as prednisolone, for a long time. Some types of cancer treatment can also increase your risk of getting osteoporosis. Risedronate can also help people who have
Paget's disease of bone. This weakens your bones and can bend them out of shape. Risedronate comes as tablets and is only available on prescription. 3. Who can and can't take risedronateRisedronate can be taken by adults aged 18 and over. It's occasionally prescribed for children with osteoporosis. Risedronate is not suitable for some people. To make sure it's safe for you, tell your doctor if you:
4. How and when to take itRisedronate comes as a tablet that you take once a week, or as a tablet that you take once a day. Follow your doctor's instructions about exactly how and when to take your medicine. If you're taking a weekly dose, you need to take your medicine on the same day each week, so choose a day that suits your routine. How much will I take?Paget's disease of bone – the usual dose for adults is 30mg, taken once a day Osteoporosis the usual dose for most adults is 35mg taken once a week. You may prefer to take 5mg, once a day How to take itRisedronate works best when your stomach is empty, so your body can absorb it properly. It's important to take risedronate while you're sitting up or standing. Stay upright for 30 minutes after taking your medicine – you can be sitting, standing or walking. Take your medicine first thing in the morning, when you get up. Take it on an empty stomach, at least 30 minutes before you have anything to eat or drink (other than plain tap water) and before you take any other medicines or supplements. Swallow the tablet whole with a large glass of plain tap water (at least 120ml). Do not chew, break, crush or suck the tablet. Do not take it with mineral water. It's important to follow the instructions for this medicine very carefully. If you do not, it may not work or it could irritate and damage your food pipe as you swallow it. If you usually take risedronate once a day and you're unable to take your tablet in the morning, you can take it later in the day. However, it's important not to eat or drink anything (other than plain water) and not to take any other medicines or supplements by mouth either 2 hours before or 2 hours after taking the tablet. What if I forget to take it?It depends how often you're supposed to take risedronate. If you usually take it: once a day – take it later in the day following the instructions above about taking it on an empty stomach If this is not possible, then just take your next dose on the following day, in the morning once a week – wait until the next day and then take your medicine first thing in the morning. After this, go back to taking your weekly dose on your usual day If you take riseodranoate once a week, some packaging has a space to mark the day of the week and the dates you take your tablets. This can help you remember to take your medicine on the right day. Never take 2 doses to make up for a forgotten one. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. What if I take too much?If you take an extra dose of:
If your child takes an extra dose, get them to drink a full glass of milk immediately. Contact their doctor straight away. Keep your child sitting up or standing for at least 30 minutes. Do not make yourself or your child sick (vomit), as this may irritate your, or your child's, food pipe. 5. Side effectsLike all medicines, risedronate can cause side effects in some people but many people have no side effects or only minor ones. Common side effectsThese common side effects happen in more than 1 in 100 people. Talk to your doctor or pharmacist if the side effects bother you or do not go away:
Serious side effectsSome people may have serious side effects when taking risedronate. Tell a doctor straight away if you have:
Serious allergic reactionIn rare cases, risedronate may cause a serious allergic reaction (anaphylaxis). Immediate action required: Call 999 or go to A&E if:
You could be having a serious allergic reaction and may need immediate treatment in hospital. These are not all the side effects of risedronate. For a full list, see the leaflet inside your medicine packet. Information: You can report any suspected side effect to the UK safety scheme. 6. How to cope with side effectsWhat to do about:
7. Pregnancy and breastfeedingRisedronate is not usually recommended during pregnancy. This is because there has not been enough research into its safety. Risedronate and breastfeedingAlthough it's generally safe to take this medicine while breastfeeding, it may not be suitable in some cases. Check with your doctor about what's best for you and your baby. Non-urgent advice: Tell your doctor if you're:
8. Cautions with other medicinesWhen taking risedronate, it's important to not take any other medicines at the same time. This is because they can interfere with how well your body absorbs risedronate and may stop it working properly. If you take risedronate first thing in the morning, when you get up, wait for at least 30 minutes before taking your other medicines. If you take risedronate between meals or in the evening, wait at least 2 hours before taking your other medicines. Tell your doctor if you're taking:
Mixing risedronate with herbal remedies or supplementsThere's very little information about taking herbal remedies and supplements with risedronate. Important: ImportantFor safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. 9. Common questionsHow does risedronate work? In osteoporosis, risedronate slows down the cells that break down bone. This maintains bone density and makes your bones stronger and less likely to break. In Paget's disease of bone, risedronate reduces the abnormal bone turnover that this condition causes. This helps to reduce deformity and pain and makes your bones stronger and less likely to break. How long does it take to work? For osteoporosis, risedronate usually starts to work after 2 weeks. However, it may take 6 months for the medicine to fully protect your bones. When used for Paget's disease of bone, risedronate reduces bone pain, but it may take 3 to 6 months for your symptoms to improve. How long will I take it for? Exactly how long depends on why your doctor has prescribed it. For Paget's disease of bone, risedronate is usually taken for 2 months. You may need to start taking it again if your symptoms come back. For osteoporosis, you'll usually take risedronate for a long time. If you're having long-term treatment with steroids, you'll usually take risedronate until your steroid treatment stops – maybe longer. If you have osteoporosis, your doctor will usually assess your risk of broken bones after 5 years. This may include tests to check the strength (density) of your bones. Depending on the results, you'll either keep taking risedronate, take a break from it or stop taking it completely. How long do the effects last after I stop taking it? Once you stop taking risedronate the effects of the medicine will gradually wear off. Your bones may continue to benefit for up to 1 year afterwards. Is it safe to take long term? Risedronate is generally prescribed for a long time. While you're taking it, you're less likely to break a bone. In a very small number of people, taking risedronate for more than 2 years can increase their chances of getting a rare type of bone damage in their inner ear and certain types of breaks to their thigh bones. If risedronate works for you long-term, your doctor will look at the benefits and risks of your treatment after 5 years. Then they'll decide if you should keep taking it. This may involve some tests to check the strength (density) of your bones. The benefits of taking risedronate generally outweigh the risks. If you're concerned or have any questions, talk to your doctor or pharmacist. What happens if I do not take it? Missing the odd dose probably will not affect the health of your bones. But if you keep forgetting to take your risedronate or you do not want to take it, for whatever reason, then speak to your doctor. There are other treatments that can help your bones. Any treatment can have side effects. But the benefits of risedronate usually far outweigh the risks. By not having treatment, you're more likely to break a bone. Broken bones are painful and can have serious consequences. In older people, for example, a broken hip can mean they're no longer able to live independently. Are there other medicines for osteoporosis? Risedronate is a bisphosphonate. Bisphosphonates are the main group of medicines used for osteoporosis and they are usually the first treatment given. Bisphosphonates all work in the same way. Other bisphosphonate medicines include:
If you cannot take a bisphosphonate medicine, there are some other options. These include denosumab, raloxifene, teriparatide and hormone replacement therapy. Your doctor will find the right medicine for you depending on your medical history. What can I do to keep my teeth healthy while taking it? It's important to take good care of your teeth while you're taking risedronate. This is because risedronate might affect your jawbone. Keep your teeth clean and have a dental check-up every 6 months. Your doctor may also recommend a dental check-up before your treatment starts. Contact your doctor or dentist if you have any problems with your mouth or teeth – such as pain, swelling or loose teeth. What happens if I need dental treatment? If you're having dental implants or having a tooth out while taking risedronate, there's a very small chance of damage to your jawbone. For safety, tell your dentist that you're taking risedronate. They may recommend a different type of dental treatment. Will risedronate affect my arthritis? Some types of arthritis and arthritis medicines can increase your risk of getting osteoporosis. Taking risedronate reduces this risk. If you have arthritis, let your doctor know if the pain or swelling in your joints gets worse when you start taking risedronate. Will it affect my fertility? There's no firm evidence to suggest that taking risedronate will reduce fertility in either men or women. However, if you're trying to get pregnant speak to a pharmacist or your doctor before taking risedronate. This is because there is not enough evidence to say that this medicine is safe to take in pregnancy. Will it affect my contraception? Can I drive or ride a bike? Yes, risedronate will not affect you being able to drive or cycle. Is there any food or drink I need to avoid? You can eat or drink normally while taking risedronate, however, it's important to take it on an empty stomach, with plain tap water not mineral water. Can I drink alcohol with it? Yes, you can drink alcohol while taking risedronate. However, drinking a lot of alcohol affects the strength of your bones and can increase your risk of breaks (fractures). Try not to drink more than 14 units of alcohol a week. A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units. Can lifestyle changes help? You can help keep your bones healthy by making some key lifestyle changes.
What medications put you at risk for osteoporosis?The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Which medication should be prescribed for osteoporosis?Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.
What drugs should not be taken with alendronate?Calcium or iron supplements, vitamins, antacids, coffee, tea, soda, mineral water, calcium-enriched juices, and food can decrease the absorption of alendronate. Do not take these for at least 30 minutes (preferably 1 to 2 hours) after taking alendronate.
What are 3 treatments used for the treatment and prevention of osteoporosis?Alendronate (Binosto, Fosamax) Ibandronate (Boniva) Risedronate (Actonel, Atelvia) Zoledronic acid (Reclast, Zometa)
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