Biochimica et Biophysica Acta [BBA] - Molecular Cell Research
Volume 1866, Issue 12, December 2019, 118540
ReviewMitochondrial acyl carrier protein [ACP] at the interface of metabolic state sensing and mitochondrial function
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Highlights
Eukaryotic mitochondria have a full set of discrete enzymes for de novo synthesis of fatty acid in an ACP-dependent manner.
MtACP interacts with complex I, assembly components of respiratory complexes, mitoribosomes and the Fe-S cluster synthesis.
Most of these interactions are transmitted through proteins of the leucine-tyrosine-arginine motif [LYRM] family.
MtFAS-generated acyl-ACPs act as signaling molecules at the interface of mitochondrial metabolic state and respiration.
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Keywords
ACP
Mitochondrial FAS
Mitochondrial respiratory chain
LYRM proteins
Fe-S cluster
Lipoic acid
Mitoribosome
Regulation
Lipids
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